FWIW, it appears to me that he's truly out of the picture since AQ is confirming the story. I was struck by how relatively impotent AQ itself had become, and ObL in particular, as the best he's been able to muster for years have been meancing audio tapes.
I'm wondering if this will accelerate NATO's withdraw from Afghanistan? My guess is that there is an awareness of the potential threat the Pakistani nuclear arsenal represts if/when the nation becomes controlled by a hard fundamentalist Islamic government. With that in mind, I'm guessing there is a strong interest in keeping an ability to intervene in the neighborhood, even if it were not out of Afghanistan.